The ~45 psi is straight from the Cummins Big Cam manual. it is measured at the lower water rail (where heater lines hook up) there is a "compucheck" fitting there to measure it.
Yes, we both agree that there has to be a difference in pressure for there to be flow. I always knew block pressure was higher but until I got deep into Big Cams, I didn't know it was that high. Pressure in the upper water rail is considerably less, as there are restrictor washers between the head and upper water rail (on Big Cam 4's). It was Glenn Akers who clued me on the higher pressure. I wasn't saying it is that high all over, just in the block. The Big Cam 4's and NT88's use waterpumps that differ from the earlier Big Cams, The 4 water pump looks similar to the -3 and down but has an extra bleed hole and is turned at a fast speed (smaller pulley) then the -3's and down. Many a person has made the mistake of installing the wrong pump and having problems because of it.
The upper water rail, bypass, return from the radiator as well as the "bottom fill" line from the top tank are kept at radiator cap pressure, most often 8-12 PSI. The Big Cam 4 and NT88's are a whole 'nother topic as they have essentially 2 coolant loops that are in motion at all times, and come together in the water pump.
Antifreeze mixture when it changes from liquid to gas doesn't change the chemical make up. Just like R 134a is the same chemical when it is in a gas or liquid form.
While writing this, KT replied, and is better suited to explaining, I would love to hear more from him.
Here is the liner re-used and spec for block pressure (max pressure 50 PSI). The cavitation happens 90 degs from the crankshaft centerline, so to re-use you rotate the liner so the damage is inline with the crankshaft.
Sorry about one right side up and the other upside down in the attachment, I can't seam to flip just one.
Cumminsspec.pdf