I got a 6V53T on my hand and I'm walking around with the same thoughts as you. I have some practical experience with turbos building a 2L gasoline with turbo, but for diesels I have only done maintenance, but I had a heavy interest in the subject and have read some turbo theory and had to do some calculations on it while I was studying for becoming a marine chief engineer. Because of my background in marine I have taken a different approach than you and instead looked at the large B&W and sulzer diesels where the construction is quile similar to the detroit, but the root's blower is gone. Instead they have a electrical blower that supply the engine on low load and at startups. I have also looked at man diesels jet assist system where compressed air from 30bar bottles are injected to help spin the compressor wheel. I think that trowing off the blower would benefit the whole construction since it would save some weight and some hp. My last idea(it's all in my head at this stage) was to use twin turbos merging into one collector supporting the larger turbo with exhaust. Doing this would allow me to use a crossover from the bank to the other so that one turbo could be sealed off using throttle bodies using only one turbo witch would give a good low end response. Once at a certain rpm and boost level the second turbo could be engaged by opening the throttles so it would become a sequential compound setup using 3 turbos. This could be combined with a low budget electrical supercharger (I know they are piss, but they could be used for this) to start the circulations of air at startup and a 12V compressor could provide compressed air to spool the turbo. Advantages would be good fuel economy. Less parts that could break. Less maintenance. More power with same mechanical load. Disadvantages would hight cost of buying the turbos. Much tuning time to make it work, Probably require some programing skills if a sequential should work without too much trouble. You would become the freak for thinking out of the box.